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This product is not intended for adults under the age of 18. Seek Doctors approval if under the care of any other prescription drug, currently have any major heart condition or if you are pregnant or about to become pregnant. Some amazing clinical findings of the benefits from Nitric Oxide are still awaiting FDA approval. The Pharmaceutical Industry would take a plunge of more than half in sales of the medicine they produce and sell to consumers if the FDA approved all the great benefits that our Universities, Doctors and Medical labs have proven in their studies the benefits from Nitric Oxide supplementation.